4Q6R: Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor 6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile

PDB ID: 4Q6RDownload
MMDB ID: 120154
PDB Deposition Date: 2014/4/23
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4Q6R: dimeric; determined by author and by software (PISA)
Molecular Components in 4Q6R
Label Count Molecule
Proteins (2 molecules)
2
Sphingosine-1-phosphate Lyase 1
(Gene symbol: SGPL1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
SUCCINIC ACIDSUCCINIC ACID
2
1
GLYCEROLGLYCEROL
3
2
6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
4
1
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303