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4RIY:
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
PDB ID:
4RIY
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MMDB ID:
125453
PDB Deposition Date:
2014/10/7
Updated in MMDB:
2014/12
Experimental Method:
x-ray diffraction
Resolution:
2.981 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4RIY: dimeric; determined by author and by software (PISA)
Molecular Components in 4RIY
Label
Count
Molecule
Proteins (2 molecules)
A
1
Receptor Tyrosine-protein Kinase Erbb-3
(Gene symbol:
ERBB3
)
B
1
Epidermal Growth Factor Receptor
(Gene symbol:
EGFR
)
Chemicals and Non-standard biopolymers (4 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
MAGNESIUM ION
3
1
ADENOSINE-5'-DIPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303