5XGH: Crystal structure of PI3K complex with an inhibitor

PDB ID: 5XGHDownload
MMDB ID: 161254
PDB Deposition Date: 2017/4/13
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 2.97  Å
Source Organism:
Similar Structures:
Biological Unit for 5XGH: dimeric; determined by author and by software (PISA)
Molecular Components in 5XGH
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol
2
1
GLYCEROLGLYCEROL
3
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303