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6O0M:
crystal structure of BCL-2 F104L mutation with venetoclax
PDB ID:
6O0M
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MMDB ID:
175653
PDB Deposition Date:
2019/2/16
Updated in MMDB:
2019/12
Experimental Method:
x-ray diffraction
Resolution:
1.75 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6O0M: monomeric; determined by author and by software (PISA)
Molecular Components in 6O0M
Label
Count
Molecule
Protein (1 molecule)
A
1
Apoptosis Regulator Bcl-2,bcl-2-like Protein 1,apoptosis Regulator Bcl-2
(Gene symbol:
BCL2
)
Chemicals and Non-standard biopolymers (5 molecules)
1
1
4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
2
4
DI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303