6OQA: Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product

PDB ID: 6OQADownload
MMDB ID: 186963
PDB Deposition Date: 2019/4/26
Updated in MMDB: 2020/05
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6OQA: tetrameric; determined by author
Molecular Components in 6OQA
Label Count Molecule
Proteins (4 molecules)
2
Peptidyl-prolyl Cis-trans Isomerase Fkbp1a
(Gene symbol: FKBP1A)
Molecule annotation
2
Centrosome-associated Protein Cep250
(Gene symbol: CEP250)
Molecule annotation
Chemicals and Non-standard biopolymers (31 molecules)
1
2
(3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione(3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione
2
13
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
7
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
4
2
3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL
5
3
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
6
3
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
7
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303