6QUW: Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 9b

PDB ID: 6QUWDownload
MMDB ID: 178063
PDB Deposition Date: 2019/2/28
Updated in MMDB: 2019/09
Experimental Method:
x-ray diffraction
Resolution: 1.242  Å
Source Organism:
Similar Structures:
Biological Unit for 6QUW: dimeric; determined by author and by software (PISA)
Molecular Components in 6QUW
Label Count Molecule
Proteins (2 molecules)
2
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
(3~{a}~{R},8~{b}~{S})-2,2,3~{a},8~{b}-tetramethyl-3,4-dihydro-1~{H}-pyrrolo[2,3-b]indole(3~{a}~{R},8~{b}~{S})-2,2,3~{a},8~{b}-tetramethyl-3,4-dihydro-1~{H}-pyrrolo[2,3-b]indole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303