7PIU: Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution

PDB ID: 7PIUDownload
MMDB ID: 208991
PDB Deposition Date: 2021/8/23
Updated in MMDB: 2021/11
Experimental Method:
electron microscopy
Resolution: 2.58  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 7PIU: hexameric; determined by author and by software (PISA)
Molecular Components in 7PIU
Label Count Molecule
Proteins (6 molecules)
1
Melanocortin Receptor 4
Molecule annotation
1
Setmelanotide (Other Names Rm-493; Bim-22493; Irc-022493; Imcivree)
Molecule annotation
1
Isoform Gnas-2 of Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Camelid Antibody Fragment - Nanobody 35
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
CALCIUM ION (Link to PubChem not yet available)CALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303