Display Settings:

Format

Send to:

Choose Destination
Accession: PRJNA101295 ID: 101295

Comprehensive analysis of PPARa-dependent regulation of hepatic lipid metabolism by expression profiling

PPARalpha is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARalpha in hepatic lipid metabolism, many PPARalpha-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARalpha-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARalpha target genes, livers from several animal studies in which PPARalpha was activated and/or disabled were analyzed by Affymetrix GeneChips. Numerous novel PPARalpha-regulated genes relevant to lipid metabolism were identified. Out of this set of genes, eight genes were singled out for study of PPARalpha-dependent regulation in mouse liver and in mouse, rat, and human primary hepatocytes, including thioredoxin interacting protein (Txnip), electron-transferring-flavoprotein beta polypeptide (Etfb), electron-transferring-flavoprotein dehydrogenase (Etfdh), phosphatidylcholine transfer protein (Pctp), endothelial lipase (EL, Lipg), adipose triglyceride lipase (Pnpla2), hormone-sensitive lipase (HSL, Lipe), and monoglyceride lipase (Mgll). More...
AccessionPRJNA101295; GEO: GSE8316
TypeUmbrella project
Publications
  • Ullah MO et al., "An Integrated Statistical Approach to Compare Transcriptomics Data Across Experiments: A Case Study on the Identification of Candidate Target Genes of the Transcription Factor PPARα.", Bioinform Biol Insights, 2012;6:145-54
  • Rakhshandehroo M et al., "Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling.", PPAR Res, 2007;2007:26839
SubmissionRegistration date: 24-Jul-2007
Nutrition, Metabolism & Genomics Group, Div. Human Nutrition & Health, Wageningen University
RelevanceSuperseries
Project Data:
Resource NameNumber
of Links
Publications
PubMed2
PMC2
Other datasets
GEO DataSets6
GEO Data Details
ParameterValue
Data volume, Spots1359757
Data volume, Processed Mbytes34
Data volume, Supplementary Mbytes160
Comprehensive analysis of PPARa-dependent regulation of hepatic lipid metabolism by expression profiling encompasses the following 5 sub-projects:
Project TypeNumber of Projects
Transcriptome or Gene expression5
BioProject
accession
NameTitle
PRJNA105443Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 5Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 5 (Nutrition, Metabolism & Genomics...)
PRJNA105431Mus musculusComprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 1 (Nutrition, Metabolism & Genomics...)
PRJNA105433Mus musculusComprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 2 (Nutrition, Metabolism & Genomics...)
PRJNA105435Mus musculusComprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 3 (Nutrition, Metabolism & Genomics...)
PRJNA105437Mus musculusComprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 4 (Nutrition, Metabolism & Genomics...)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center