See
Genome Information for Oryzias latipes
A global RNA-Seq analysis was conducted using RNA isolated from the axial region of DMSO- and 0.3 nM TCDD-exposed medaka to identify targets within the osteochondral pathway potentially impacted by TCDD exposure. In total, 597 genes were significantly up- or down-regulated (q<0.05) and were associated with select pathological states including inflammatory disease, connective tissue disorders, and skeletal and muscular disorders.
Overall design: RNA was isolated from axial tissue (containing vertebrae and surrounding muscle, fat, and dermis) from Japanese medaka larvae. Whole transcriptome libraries from DMSO and TCDD-medaka were generated for downstream RNA-Seq using the Ion Torrent PGM platform.
| Accession | PRJNA343774; GEO: GSE87168 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Oryzias latipes[Taxonomy ID: 8090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias; Oryzias latipes |
| Publications | Watson AT et al., "From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes.", Toxicol Sci, 2017 Feb;155(2):485-496 |
| Submission | Registration date: 21-Sep-2016
North Carolina State University |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 6 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 6 |
| GEO DataSets | 1 |