BioProject

The findings in our study revealed dynamic differences of gene expression and different pathways of immune response in mice infected with three distinct strains of T. More...

The findings in our study revealed dynamic differences of gene expression and different pathways of immune response in mice infected with three distinct strains of T. gondii. Overall design: We conducted a time course study of gene expression in CD-1 outbred mice during acute infection (days 1 to 7) with the highly virulent type I (GT1 strain), intermediately virulent type II (PTG strain) and non-virulent type III (CTG strain) parasites. Mice were infected with 500 parasites by intraperitoneal injection. Three to 4 mice were euthanized on day 1, 2, 3, 4, 5 and 7 post infection, respectively. Peritoneal cells were collected for RNA extraction and gene expression study. Less...