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Accession: PRJNA764444 ID: 764444

Role of SIRT1 in NAMPT-induced liver gene expression (house mouse)

See Genome Information for Mus musculus
We tested they hypothesis that hepatocyte SIRT1 mediates transcriptomic changes induced by hepatocyte-specific NAMPT overexpression Overall design: We overexpressed NAMPT in western diet-fed WT and SIRT1 liver-specific knockout mice for 12wk and subjected liver tissue to high-throughput RNA sequencing
AccessionPRJNA764444; GEO: GSE184394
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsHiggins CB et al., "SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase.", Nat Commun, 2022 Feb 28;13(1):1074
SubmissionRegistration date: 18-Sep-2021
Brian DeBosch, Pediatrics and Cell Biology & Physiology, Washington University School of Medicine
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments25
Publications
PubMed1
PMC1
Other datasets
BioSample25
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes66
SRA Data Details
ParameterValue
Data volume, Gbases209
Data volume, Mbytes75540

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