Transcriptome analysis of LRRK2 knock-out microgli... (ID 774051) - BioProject

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Accession: PRJNA774051 ID: 774051

Transcriptome analysis of LRRK2 knock-out microglia cells reveals T alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils (house mouse)

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66502 additional projects are related by organism.

We used the RNA-Sequencing to obtain transcriptomic profiles of LRRK2 wild-type (WT) and knock-out (KO) microglia cells treated with α-synuclein pre-formed fibrils (PFFs) or lipopolysaccharide (LPS) as a general inflammatory insult. More...

Accession	PRJNA774051; GEO: GSE186483
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
Publications	Mamais A et al., "Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.", PLoS Biol, 2021 Dec;19(12):e3001480 Russo I et al., "Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.", Neurobiol Dis, 2019 Sep;129:67-78
Submission	Registration date: 24-Oct-2021 Laboratory of Neurogenetics, National Institutue on Aging, NIH
Relevance	Model Organism

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	30
Publications
PubMed	2
PMC	2
Other datasets
BioSample	30
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	3

SRA Data Details

Parameter	Value
Data volume, Gbases	259
Data volume, Tbytes	0.11

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Transcriptome analysis of LRRK2 knock-out microglia cells reveals T alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils (house mouse)

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