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Accession: PRJNA782200 ID: 782200

RNA-seq data from pharmacological inhibition of the G9a histone methyltransferase with UNC0642 in SAMP8 mice (house mouse)

See Genome Information for Mus musculus
Purpose: The aim of this study is to compare brain transcriptome profile (RNA-seq) after G9a inhibition. Methods: Hippocampus profiles of 7-month-old SAMP8 Control and SAMP8 Treated mice groups were generated by deep sequencing, pooled using Ilumnia Hiseq. Results: G9a inhibition with UNC0642 induces a transcriptional profile that allows beneficial effects on cognitive performance. Differential expression analysis identified 697 differentially expressed genes (DEG) (fold change cutoff of ≥1.3, p-value<0.05). Of which 217 are reduced, and 480 are increased in SAMP8 UNC0642. Conclusions: Our study showed the first transcriptome analysis of whole brain after G9a inhibition, generated by RNA-seq technology, demonstrating transcriptomic changes. Overall design: Hippocampus mRNA profiles after G9a inhibition in SAMP8 mice
AccessionPRJNA782200; GEO: GSE189249
Data TypeTranscriptome or Gene expression
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
SubmissionRegistration date: 20-Nov-2021
Neuropharmacology in Aging and Neurodegeneration, Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments2
Other datasets
GEO DataSets1
GEO Data Details
Data volume, Supplementary Mbytes1
SRA Data Details
Data volume, Gbases37
Data volume, Mbytes11834

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