BioProject

Irisin is thought to be produced by muscles as an actin. This project was undertaken by synthesising a natural polymer based injectable hydrogel encapsulating Irisin, called I OG hydrogel, and injecting it into the tibiae of aseptic loose mice. More...

Irisin is thought to be produced by muscles as an actin. This project was undertaken by synthesising a natural polymer based injectable hydrogel encapsulating Irisin, called I OG hydrogel, and injecting it into the tibiae of aseptic loose mice. After 5 weeks of treatment, we analysed differential mRNA expression in tibiae between each group. It was demonstrated that I OG hydrogel inhibited the development of aseptic loosening by modulating integrin pathway, Wnt pathway and inflammatory pathway. Less...