BioProject

Excessive Ang II signaling through AT1R is shown to cause pathological hypertrophy. More...

Excessive Ang II signaling through AT1R is shown to cause pathological hypertrophy. Underlying molecular mechanisms are not yet known and expression studies are not available so far. To understand hAT1R signaling, cardiac tissue, from C57BL/6 mouse over expressing hAT1R signaling, is subjected to genomic microarray studies. This data compared with the data from healthy, non transgenic C57BL/6 mouse. Keywords: disease state analysis Overall design: Mouse heart tissues are collected from age matched and gender matched samples. RNA is isolated using commercial kits as per the manufacturer's instructions and subjected to quality checks before experiments. cRNA preparation, pre hybridization, hybridization and post hybridization were carried out Genomics core facility, Case western reserve university. 3 chips for each category were taken for present analysis. Less...