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The study outcome was to evaluate the effect of the time on tumor samples and possibly select specific genes whose expression is time-related, that could be used as detectors of tissue degradation.
Overall design: RNA extracted from specimens of 14 patients at four time points after surgery was analyzed for gene expression on high-density oligonucleotide microarrays. A mixed-effects model implemented by considering the factor time (T0, T1, T2, T3) as fixed and the factor patient as random was used to identify probes with different expression means across the four different time points. The p-values of the model were adjusted with the Bonferroni method (p<0. 05).
| Accession | PRJNA158651; GEO: GSE37178 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Musella V et al., "Effects of warm ischemic time on gene expression profiling in colorectal cancer tissues and normal mucosa.", PLoS One, 2013;8(1):e53406 |
| Submission | Registration date: 11-Apr-2012
Fondazione IRCCS Istituto Nazionale dei Tumori |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 4099452 |
| Data volume, Processed Mbytes | 123 |
| Data volume, Supplementary Mbytes | 18 |