Homo sapiens (ID 178110) - BioProject

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Accession: PRJNA178110 ID: 178110

Homo sapiens (human)

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (gene expression)

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This project is a component of the Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes

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1 additional project is a component of the Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes.

90627 additional projects are related by organism.

A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me. More...

Accession	PRJNA178110; GEO: GSE41676
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications	Han H et al., "Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells.", PLoS One, 2013;8(9):e75136
Submission	Registration date: 17-Oct-2012 USC/Norris Comprehensive Cancer Center
Relevance	Medical

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Resource Name	Number of Links
Publications
PubMed	1
PMC	1
Other datasets
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Spots	1133528
Data volume, Processed Mbytes	51

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Homo sapiens (human)

Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (gene expression)

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