See
Genome Information for Rattus norvegicus
Coexpression of alpha-synuclein and p25alpha in an oligodendroglial cell line elicites a degenerative response that relies on aggregation and phosphorylation of alpha-synuclein at Ser129
We used microarray analysis to detail the changes in gene expression caused by alpha-synuclein aggregation followed by cellular degeneration
Overall design: Alpha-synuclein was coexpressed with p25alpha in an oligodendroglial cell line and mRNA was isolated at 8, 12, and 16 hrs after transfection. Gene expression was analyzed by two identical microarray set-ups
| Accession | PRJNA225019; GEO: GSE51781 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Rattus norvegicus[Taxonomy ID: 10116] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus |
| Publications | Kragh CL et al., "Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.", Neurobiol Dis, 2014 Mar;63:171-83 |
| Submission | Registration date: 28-Oct-2013
Biomedicine, Aarhus University |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 2 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 373188 |
| Data volume, Processed Mbytes | 6 |
| Data volume, Supplementary Mbytes | 40 |