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Accession: PRJNA237758 ID: 237758

Mus musculus (house mouse)

WT and FcgKO peritoneal MF response to IL4

See Genome Information for Mus musculus
Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. Using functional and gene expression analysis we describe the role for the tonic signaling through Fcg-chain, the major ITAM-module of the innate immune system, in modifying cytokine responses in MF. Overall design: Peritoneal MF were left unstimulated or were stimulated in duplicates for 6 hrs with IL4. cDNA was analyzed using 8-sample Mouse Ref-8 v2.0 Illumina array. Expressed genes were defined as those with p<0.05, and their relative expression values were calculated using average of two WT unstimulated samples as calibrator.
AccessionPRJNA237758; GEO: GSE54823
Data TypeTranscriptome or Gene expression
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsBezbradica JS et al., "A role for the ITAM signaling module in specifying cytokine-receptor functions.", Nat Immunol, 2014 Apr;15(4):333-42
SubmissionRegistration date: 10-Feb-2014
Immunobiology, Yale University
RelevanceModel Organism
Project Data:
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GEO DataSets1
GEO Data Details
Data volume, Spots205576
Data volume, Processed Mbytes6
Data volume, Supplementary Mbytes2

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    Mus musculus
    WT and FcgKO peritoneal MF response to IL4

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