Rhabdoid Tumors (RT) are highly aggressive tumors that are frequently localized in the central nervous system (CNS) where they are termed atypical teratoid and rhabdoid tumors (ATRT). We generated conditional Smarcb1-deficient mouse model leads to CNS Smarcb1-deficient tumors.
We used microarrays to compared gene expression profilings of various human and mouse tumors. Our data demonstrate that the Smarcb1-deficient mouse model recapitulates the diversity of human RT.
Overall design: [human mRNA] 20 human MRT ( < 5 years), 30 human ATRT ( < 5 years), 4 human MB SHH.
[mouse mRNA] 8 Smarcb1-deficient mouse brain tumors, 15 Smarcb1-deficient T-Cell lymphomas, 3 Mb Shh mouse tumors.
| Accession | PRJNA269772; GEO: GSE64019 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multispecies |
| Publications | Han ZY et al., "The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation.", Nat Commun, 2016 Jan 28;7:10421 |
| Submission | Registration date: 9-Dec-2014
Institut Curie |
| Relevance | Unknown |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 1482122 |
| Data volume, Processed Mbytes | 30 |
| Data volume, Supplementary Mbytes | 373 |