BioProject

Commensal streptococcal species in the oral cavity adhere to the salivary pellicle coating tooth surfaces by various means. More...

Commensal streptococcal species in the oral cavity adhere to the salivary pellicle coating tooth surfaces by various means. Several streptococcal species utilize amylase-binding proteins to attach to α-amylase, the most predominant protein in saliva. A screen of the supernatants of 76 strains representing 13 streptococcal species detected several ABPs based on an in vitro amylase-ligand binding assay and N-terminal protein sequencing. To rapidly determine the genetic sequence associated with each of these proteins, the genomes of eighteen strains representing these streptococcal species have been sequenced (DNA-Seq), assembled, and annotated. The goal of this study is to determine the evolution of ABPs through phylogenetic analysis of these sequences. Less...