Loss of cyclin A2 in murine colonic epithelial cel... (ID 629794) - BioProject

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Accession: PRJNA629794 ID: 629794

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer (house mouse)

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To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). More...

Accession	PRJNA629794; GEO: GSE149716
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
Publications	Guo Y et al., "Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.", J Clin Invest, 2021 Feb 15;131(4)
Submission	Registration date: 1-May-2020 Institut Paoli-Calmettes
Relevance	Model Organism

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	8
Publications
PubMed	1
PMC	1
Other datasets
BioSample	8
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	3

SRA Data Details

Parameter	Value
Data volume, Gbases	98
Data volume, Mbytes	44601

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Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer (house mouse)

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