To define mechanisms by which SBDS deficiency in bone marrow (BM) niches impairs donor hematopoietic stem cell engraftment after transplantation, we performed RNA-seq on the BM stromal cells from Sbds-deficient mice versus control mice at 24 hours after myeloablative total body irradiation (TBI) and at baseline.
Accession | PRJNA763892 |
Data Type | Raw sequence reads |
Scope | Multispecies |
Grants | - "Targeting the Marrow Niche to Improve Stem Cell Transplantation" (Grant ID N/A, W.W. Smith Charitable Fondation)
- "Improving Stem Cell Niche Function during Cellular Therapy for Leukemia Predisposition Syndromes" (Grant ID N/A, The Hyundai Hope on Wheels)
- "Bone Marrow Niche Targets to Prevent Cancer in Shwachman Diamond Syndrome" (Grant ID N/A, The Cure Childhood Cancer Foundation)
- "Studies of HSC Engraftment at the Osteoblastic Niche for Inherited BM Failure" (Grant ID K08 HL122306, National Heart, Lung, and Blood Institute)
- "Osteoblastic Niche Function During Stem Cell Transplantation for Inherited Bone Marrow Failure Syndromes" (Grant ID N/A, American Society of Hematology)
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Submission | Registration date: 16-Sep-2021 Children's Hospital of Philadelphia |
Project Data:
Resource Name | Number of Links |
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Sequence data |
SRA Experiments | 16 |
Other datasets |
BioSample | 16 |