GEO DataSets for BioProject (Select 147937) - GEO DataSets

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Items: 3

Select item 2000323901.

In vitro responses of PBMC and fibroblasts from patients with TRIF deficiency after TRIF dependent and independent stimuli

(Submitter supplied) We report here unrelated HSE patients with autosomal recessive (AR) or autosomal dominant (AD) TRIF deficiency. The AR form of the disease is due to a homozygous nonsense mutation, resulting in a complete absence of the TRIF protein. Both the TLR3 and the TRIF-dependent TLR4 signaling pathways are abolished. The AD form of TRIF deficiency is due to a heterozygous missense mutation resulting in a dysfunctional protein. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS4539 GDS4540
Platform:: GPL10558
27 Samples

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Series

Accession:: GSE32390

ID:: 200032390

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 45402.

TRIF-deficient Herpes simplex encephalitis patient: peripheral blood mononuclear cell response to TLR agonists LPS and R-848

Analysis of PBMCs collected from an HSV1 encephalitis (HSE) patient with TRIF deficiency (homozygous TRIF nonsense mutation) and stimulated with LPS or resiquimod hydrochloride R-848. TRIF is the sole adaptor protein for TLR3. Results provide insight into the role of the TLR3 pathway in HSE.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 agent, 2 disease state, 3 genotype/variation sets

Platform:: GPL10558
Series:: GSE32390
9 Samples

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DataSet

Accession:: GDS4540

ID:: 4540

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 45393.

TRIF-deficient Herpes simplex encephalitis patient: fibroblast response to interleukin-1β and TLR3 agonist poly (I:C)

Analysis of SV40 skin fibroblasts collected from an HSV1 encephalitis (HSE) patient with TRIF deficiency (homozygous TRIF nonsense mutation) and stimulated with IL-1β or poly I:C . TRIF is the sole adaptor protein for TLR3. Results provide insight into the role of the TLR3 pathway in HSE.