GEO DataSets for BioProject (Select 117507) - GEO DataSets

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Items: 2

Select item 2000167981.

Genes regulated after knock-down of Pirin in U937 cells

(Submitter supplied) Pirin (PIR) is a putative transcriptional regulator whose expression is silenced in cells bearing the AML1/ETO and PML/RAR leukemogenic fusion proteins and is significantly repressed in a large proportion of acute myeloid leukemias. PIR expression increases during in vitro myeloid differentiation of primary hematopoietic precursor cells, and ablation of PIR in the U937 myelomonocytic cell line or in murine primary hematopoietic precursor cells results in impairment of terminal myeloid differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5254
Platform:: GPL570
4 Samples

Download data: CEL

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Accession:: GSE16798

ID:: 200016798

Select item 52542.

Pirin depletion effect on myelomonocytic cell line

Analysis of U937 myelomonocytic cells depleted for Pirin. Pirin is silenced in cells with the acute myeloid leukemia-1 eight-twenty-one and promyelocytic leukemia/retinoic acid receptor leukemogenic fusion proteins. Results provide insight into the role of Pirin in myeloid differentiation.