GEO DataSets for BioProject (Select 177176) - GEO DataSets

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Items: 2

Select item 2000414851.

Expression data of A939572 SCD1 inhibitor treated ccRCC cells

(Submitter supplied) Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5094
Platform:: GPL570
8 Samples

Download data: CEL

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Accession:: GSE41485

ID:: 200041485

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50942.

Stearoyl-CoA desaturase 1 inhibition effect on clear cell renal cell carcinoma cell lines

Analysis of clear cell renal cell carcinoma (ccRCC) cells treated with A939572, a stearoyl-CoA desaturase 1 (SCD1) inhibitor. SCD1 is overexpressed in ccRCC.Results provide insight into the role of SCD1 in the pathogenesis of ccRCC.