GEO DataSets for BioProject (Select 224547) - GEO DataSets

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Items: 2

Select item 2000516781.

Microarray profiling of STEP knockout mouse striatum

(Submitter supplied) STEP (striatal-enriched tyrosine phosphatase) is a brain-specific phosphatase named for its robust expression in striatum. Brains from homozygous and heterozygous STEP knockout mice and wild-type littermates were harvested, and striatum microdissected. RNA was extracted and hybridized to Affymetrix 230_2 microarray chips.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5250
Platform:: GPL1261
13 Samples

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Accession:: GSE51678

ID:: 200051678

Select item 52502.

Striatal-enriched protein tyrosine phosphatase (STEP) knockout effect on striatum

Analysis of striatum from striatal-enriched protein tyrosine phosphatase (STEP)+/- and -/- littermates. Brain-specific tyrosine phosphatase STEP is associated with de-phosphorylation of several key neuronal signaling proteins. Results provide insight into role of STEP in synaptic plasticity.