GEO DataSets for BioProject (Select 284106) - GEO DataSets

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Items: 2

Select item 2000689181.

Identification of KDM3A regulated genes in the ER positive breast cancer cell line MCF-7

(Submitter supplied) Using a siRNA screen we identified the histone demethylase enzyme KDM3A as a potential positive regulator of ER signalling in breast cancer. To interrogate the full extent of KDM3A regulation on ER signalling we assessed basal and estrogen (E2)- stimulated global gene expression changes in KDM3A-depleted MCF-7 cells by microarray analysis using the Illumina Human HT12 Version 4 BeadChip array. We identified ER regulated genes affected by KDM3A knockdown and determined that KDM3A is required for ER recruitment to estrogen response elements in the promotors of ER regulated genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5662
Platform:: GPL10558
11 Samples

Download data: TXT

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Accession:: GSE68918

ID:: 200068918

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56622.

Histone demethylase KDM3A-deficiency effect on estrogen-stimulated breast cancer cells in vitro

Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.