(Submitter supplied) There is evidence for the beneficial effect of FK506, an effective immunosuppressive agent, for the treatment of asthma; however, the mechanisms underlying these effects are unclear. Using a mouse model of airway inflammation induced by Papain, a protease allergen, and RNAseq analysis of lung innate cells, we found that FK506 inhibited the activation of ILC2s, which initiate airway inflammation, as well as the induction of TH2 cells, which cause chronic inflammation.
more...- Organism:
- Mus musculus
- Type:
- Expression profiling by high throughput sequencing
- Platform:
- GPL18480
- 28 Samples
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