GEO DataSets for BioProject (Select 92641) - GEO DataSets

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Items: 2

Select item 2000029641.

Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines

(Submitter supplied) We report the effect of motexafin gadolinium (MGd) and exogenous zinc on intracellular levels of free zinc, oxidative stress, proliferation, cell cycle, and cell death in exponential phase human B-cell lymphoma and other hematologic cell lines. We find that increased levels of oxidative stress and intracellular free zinc precede and correlate with cell cycle arrest and apoptotic response. Treatment with exogenous zinc increased oxidative stress and, conversely, oxidative stress resulted in increased intracellular free zinc levels. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1617
Platform:: GPL570
18 Samples

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Accession:: GSE2964

ID:: 200002964

Select item 16172.

Motexafin gadolinium and zinc effect on Ramos B-cell lymphoma line

Analysis of Ramos B-cell lymphoma cultures following 4 hour treatment with anticancer agent motexafin gadolinium (MGd), zinc acetate (25 or 50 uM), or combinations of MGd and zinc. Results provide insight into the molecular changes that accompany the disruption of intracellular zinc homeostasis.