GEO DataSets for BioProject (Select 92803) - GEO DataSets

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Items: 2

Select item 2000032961.

Gene expression in MEFs in response to treatment with dipyridyl and trichostatin A

(Submitter supplied) The CH1 protein interaction domain of the transcriptional coactivators p300 and CBP is thought to interact with HIF-1alpha and this interaction is thought to be critical to the expression of HIF-1alpha target genes in response to hypoxia. Trichostatin A (TSA), an inhibitor of histone deacetylases, has been reported to repress the expression of HIF-1alpha target genes. To test the requirement of the CH1 domain and TSA for gene expression in response to dipyridyl (a hypoxia mimetic), primary mouse embryonic fibroblasts (MEFs) were generated from C57Bl/6x129/Sv F2 e14.5 embryos that contain a deletion in the CH1 domain of three of four alleles of CBP and p300. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2162
Platform:: GPL1261
16 Samples

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Accession:: GSE3296

ID:: 200003296

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 21622.

CH1 domain deletion, p300 and CBP heterozygous null mutant hypoxic fibroblasts response to trichostatin A

Analysis of trichostatin A (TSA)-treated hypoxic fibroblasts with deletions in CH1 domains of p300 and CBP, and a p300 or CBP allele knockout. TSA is a histone deacetylase inhibitor. Results provide insight into the role of deacetylase activity in CH1-independent hypoxia inducible transcription.