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Impaired revascularization in a mouse model of diabetes associated with dysregulation of angiogenic-regulatory network.

(Submitter supplied) Diabetes is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis or increased endothelial cell apoptosis. Here is it shown that angiogenic repair of ischemic hind limbs was impaired in Lepr db/db mice, a leptin receptor deficient model of diabetes, compared to wild-type C57BL/6 (WT) mice as evaluated by laser Doppler flow and capillary density analyses. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
24 Samples
Download data
Series
Accession:
GSE3313
ID:
200003313

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