GEO DataSets for BioProject (Select 96473) - GEO DataSets

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Items: 2

Select item 2000052551.

Loss of BMPR2 Signaling in Smooth Muscle in Mouse Lung

(Submitter supplied) Mice expressing a doxycycline-inducible dominant negative BMPR2 transgene expressed only in smooth muscle are activated for one or eight weeks, and compared to transactivator-only mice also fed doxycycline. All mice are 12 weeks of old at sacrifice. Keywords: time course with SM22-rtTA x tetO7-BMPR2 transgene

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2147
Platform:: GPL1261
6 Samples

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Accession:: GSE5255

ID:: 200005255

Select item 21472.

Bone morphogenic protein receptor 2 inactivation in smooth muscle effect on the lung: time course

Analysis of lungs 1 or 8 weeks following induction in smooth muscle of a dominant negative mutant form of type 2 bone morphogenic protein receptor (BMPR2). Results provide insight into the pathogenesis of hereditary pulmonary arterial hypertension (PAH), a disorder associated with BMPR2 mutations.