Abstract: Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.
This SuperSeries is composed of the SubSeries listed below.
Overall design: Refer to individual Series
| Accession | PRJNA94797; GEO: GSE4351 |
| Type | Umbrella project |
| Publications | Bohen SP et al., "Variation in gene expression patterns in follicular lymphoma and the response to rituximab.", Proc Natl Acad Sci U S A, 2003 Feb 18;100(4):1926-30 |
| Submission | Registration date: 7-Mar-2006
Stanford University, School of Medicine, Stanford Microarray Database (SMD) |
| Relevance | Superseries |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 4 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 1847040 |
| Data volume, Processed Mbytes | 391 |
This project encompasses the following 2 sub-projects:
| Project Type | Number of Projects |
| Transcriptome or Gene expression | 2 |
BioProject
accession | Organism | Title |
|---|
| PRJNA104841 | Homo sapiens | Follicular lymphoma and normal lymphoid tissue comparisons (Stanford University, School...) | | PRJNA104843 | Homo sapiens | Follicular lymphoma lymph node (Stanford University, School...) |
|