To define mechanisms by which SBDS deficiency in bone marrow (BM) niches impairs donor hematopoietic stem cell engraftment after transplantation, we performed RNA-seq on the BM stromal cells from Sbds-deficient mice versus control mice at 24 hours after myeloablative total body irradiation (TBI) and at baseline.
| Accession | PRJNA763892 |
| Data Type | Raw sequence reads |
| Scope | Multispecies |
| Grants | - "Targeting the Marrow Niche to Improve Stem Cell Transplantation" (Grant ID N/A, W.W. Smith Charitable Fondation)
- "Improving Stem Cell Niche Function during Cellular Therapy for Leukemia Predisposition Syndromes" (Grant ID N/A, The Hyundai Hope on Wheels)
- "Bone Marrow Niche Targets to Prevent Cancer in Shwachman Diamond Syndrome" (Grant ID N/A, The Cure Childhood Cancer Foundation)
- "Studies of HSC Engraftment at the Osteoblastic Niche for Inherited BM Failure" (Grant ID K08 HL122306, National Heart, Lung, and Blood Institute)
- "Osteoblastic Niche Function During Stem Cell Transplantation for Inherited Bone Marrow Failure Syndromes" (Grant ID N/A, American Society of Hematology)
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| Submission | Registration date: 16-Sep-2021
Children's Hospital of Philadelphia |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 16 |
| Other datasets |
| BioSample | 16 |