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Accession: PRJNA102091 ID: 102091

Mus musculus (house mouse)

Comparative analysis of gene expression in A/J CS vs Air lungs.

See Genome Information for Mus musculus
We hypothesize that gene expression in the CS-exposed lungs of this strain (A/J) of mice would be able to give clues about the molecular mechanism of emphysema development, thus contributing to this phenotype. More specifically, although imbalance in oxidants/antioxidants and proteinase/antiproteinase pathways drives the pathogenesis of COPD, the molecular mechanisms involved in the development of emphysema are poorly understood. In order to test this hypothesis at the gene expression level, we utilized microarray analysis to examine transcriptional differences between CS-exposed and Air-exposed groups of mice. Keywords: comparative expression profiling Overall design: This study utilizes microarray analysis to test these hypotheses. Three sets of lungs were harvested from both groups at each time point (A/J - CS exposed OR Air-exposed: 5 hr, 8 days, 1.5 mos, and 6 mos). RNA was isolated and used for global gene expression profiling (Affymetrix Mouse 430 2.0 array). Statistically significant gene expression was determined as a minimum 6 counts of 9 pairwise comparisons, minimum 1.5-fold change, and p < 0.05.
AccessionPRJNA102091; GEO: GSE8790
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsRangasamy T et al., "Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression.", Am J Physiol Lung Cell Mol Physiol, 2009 Jun;296(6):L888-900
SubmissionRegistration date: 23-Mar-2009
Clarke G Tankersley, Environmental health sciences, Johns Hopkins University School of public health
RelevanceModel Organism
Project Data:
Resource NameNumber
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Publications
PubMed1
PMC1
Other datasets
GEO DataSets2
GEO Data Details
ParameterValue
Data volume, Spots992222
Data volume, Processed Mbytes27
Data volume, Supplementary Mbytes92

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