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Accession: PRJNA118389 ID: 118389

Mus musculus (house mouse)

Analysis of altered gene expressions in valproate-treated Disc1-L100P mutant mice

See Genome Information for Mus musculus
Microarray analysis revealed that changes in genes expressions are brain region-dependent; expression of several genes are affected by point mutation L100P, which was verified by RT-PCR (Lcn2, Cyr61, Slc6a12, Slc40a1, Egr2), a few genes are affected by genotype and valproate (Dusp1 and Purb), suggesting their role in valproate-induced benificial effect on sensorimotor gaiting in Disc1-L100P mutant mice. More...
AccessionPRJNA118389; GEO: GSE17735
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsLipina TV et al., "Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.", Synapse, 2011 Mar;65(3):234-48
SubmissionRegistration date: 24-Nov-2009
Ontario Institute for Cancer Research
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots1773093
Data volume, Processed Mbytes43
Data volume, Supplementary Mbytes4401

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