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Accession: PRJNA245196 ID: 245196

Mus musculus (house mouse)

Mutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.

See Genome Information for Mus musculus
Gene expression of mouse hepatoblasts (HBs) expressing IDH1 WT, IDH1 R132C, IDH2 WT, R172K and empty vector controls (N=2 cultures for each condition) grown on collagen-coated plates and IDH1 R132C and empty vector controls on uncoated plates were evaluated using Affymetrix Mouse 430Av2 DNA microarrays that were processed at the Dana-Farber Cancer Institute core facility (http://macf-web. More...
AccessionPRJNA245196; GEO: GSE57002
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsSaha SK et al., "Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.", Nature, 2014 Sep 4;513(7516):110-4
SubmissionRegistration date: 23-Apr-2014
Cancer Center, Massachusetts General Hospital
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets3
GEO Data Details
ParameterValue
Data volume, Spots317660
Data volume, Processed Mbytes6
Data volume, Supplementary Mbytes29

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