BioProject

The genome sequences of four clinical isolates of tubercle bacilli with smooth colony morphology (hereafter referred to as smTB) to be deposited in the EMBL databases have been determined by using 4X Sanger shotgun, 16X Roche 454 and 50X Illumina sequencing, which has allowed together with an extensive finishing phase high quality draft sequences of the 4 genomes to be generated that were annotated and expert-curated by using the MaGe annotation platform at the Genoscope in Evry, France. More...

The genome sequences of four clinical isolates of tubercle bacilli with smooth colony morphology (hereafter referred to as smTB) to be deposited in the EMBL databases have been determined by using 4X Sanger shotgun, 16X Roche 454 and 50X Illumina sequencing, which has allowed together with an extensive finishing phase high quality draft sequences of the 4 genomes to be generated that were annotated and expert-curated by using the MaGe annotation platform at the Genoscope in Evry, France. The sequences are related to the Mycobacterium canettii strain (EMBL accession number PRJEA68135) recently deposited by the Sanger Institute, which is also included in this collaborative project. The genome data are of great value for reconstructing the ancestral gene pool before the clonal emergence of Mycobacterium tuberculosis and for determining the molecular events involved. Less...