In a
comparative genomics study designed to examine eukaryotic genome evolution, the
Genolevures Consortium determined the complete genome sequences of the yeast species
Yarrowia lipolytica,
Kluyveromyces lactis,
Candida glabrata, and
Debaryomyces hansenii. These four hemiascomycete yeasts represent a broad evolutionary range within a single eukaryotic phylum.
The
Genolevures Consortium sequenced the
Yarrowia lipolytica strain CLIB122 genome at 10X coverage using whole genome shotgun (WGS) sequencing. They assembled the
Yarrowia lipolytica sequences into chromosomes with 11 total gaps. The
Genolevures Consortium annotated the four yeast genome sequences, identifying approximately 24,200 novel genes. They classified the corresponding protein products, together with
Saccharomyces cerevisiae proteins, into about 4,700 families. Genomic analysis revealed that the different yeast lineages have evolved through a variety of molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication, and extensive gene loss.
Less...