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1 additional project is a component of the miRNA-seq and RNA-seq data from pharmacological inhibition of the G9a histone methyltransferase with UNC0642 in SAMP8 mice.
Purpose: The aim of this study is to compare brain transcriptome profile (RNA-seq) after G9a inhibition.
Methods: Hippocampus profiles of 7-month-old SAMP8 Control and SAMP8 Treated mice groups were generated by deep sequencing, pooled using Ilumnia Hiseq.
Results: G9a inhibition with UNC0642 induces a transcriptional profile that allows beneficial effects on cognitive performance. Differential expression analysis identified 697 differentially expressed genes (DEG) (fold change cutoff of ≥1.3, p-value<0.05). Of which 217 are reduced, and 480 are increased in SAMP8 UNC0642.
Conclusions: Our study showed the first transcriptome analysis of whole brain after G9a inhibition, generated by RNA-seq technology, demonstrating transcriptomic changes.
Overall design: Hippocampus miRNA profiles after G9a inhibition in SAMP8 mice
| Accession | PRJNA782199; GEO: GSE189248 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Bellver-Sanchis A et al., "G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.", Aging Dis, 2024 Feb 1;15(1):311-337 |
| Submission | Registration date: 20-Nov-2021
Neuropharmacology in Aging and Neurodegeneration, Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 2 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 2 |
| GEO DataSets | 1 |