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Calnexin/calreticulin cycle

The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008), but in certain cases can occur even in the absence of glycosylation (Ireland BS et al, 2008).

from REACTOME source record: R-HSA-901042
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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