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PI-3K cascade:FGFR2

The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals.

from REACTOME source record: R-HSA-5654695
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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