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GDP-L-fucose biosynthesis I (from GDP-D-mannose)

General Background |FRAME: L-Fucopyranoses| is an important monosaccharide found in a diverse array of organisms. It is a carbohydrate component of bacterial lipopolysaccharides, mammalian and plant glycoproteins (such as the human antigenic glycoproteins or glycolipids of erythrocyte membranes) and various plant cell wall polysaccharides. It is found in xyloglucans and rhamnogalacturonans I and II. Fucosylation is performed by fucosyltransferases which require the activated form |FRAME: GUANOSINE_DIPHOSPHATE_FUCOSE| (GDP-Fuc) as the donor substrate. The formation of |FRAME: GUANOSINE_DIPHOSPHATE_FUCOSE| occurs via two routes: a) a de novo synthesis route from |FRAME: GDP-MANNOSE| (this pathway), and b) a salvage pathway leading to the formation of UDP-Fuc from free |FRAME: L-Fucopyranoses| (|FRAME:PWY-6|). Key Notes on the Enzymes: The de novo synthesis of GDP-Fuc from GDP-D-mannose (GDP-Man) comprises three catalytic steps: a 4,6-dehydration, a 3,5-epimerization, and a 4-reduction. The first reaction step is catalyzed by |FRAME: GDPMANDEHYDRA-CPLX|, which involved the formation of the intermediate |FRAME: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE|. In |FRAME: TAX-3702|, the |FRAME: AT3G51160| encodes a protein which was shown to possess this catalytic activity. In bacteria (|FRAME: TAX-562|), fungi (|FRAME: TAX-64518|), plants (|FRAME: TAX-3702|) and humans, the second and third reactions steps have been shown to be catalyzed by a single bifunctional polypeptide: |FRAME: CPLX0-3881| |CITS:[12881408][9525924][8910301][20035716]|. The coexpression of Arabidopsis thaliana |FRAME: AT3G51160| and |FRAME: AT1G73250| (encoding for |FRAME: AT1G73250-MONOMER|) genes in yeast cells led to the production of GDP-Fuc from GDP-Man |CITS:[12881408]|.

from BIOCYC source record: META_PWY-66
Type: pathway
Taxonomic scope
conserved biosystem

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