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PTK6 promotes HIF1A stabilization

HBEGF-stimulated formation of EGFR heterodimers with GPNMB triggers PTK6-mediated phosphorylation and stabilization of the hypoxia inducible factor 1 alpha (HIF1A) under normoxic conditions. This process depends on the presence of a long non-coding RNA LINC01139 (LINK-A) (Lin et al. 2016).

from REACTOME source record: R-HSA-8857538
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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