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colanic acid building blocks biosynthesis

|FRAME: CPD0-1099 "Colanic acid"|, also known as the M antigen, is an extracellular polysaccharide found in |FRAME: TAX-543|. It is a polyanionic heteropolysaccharide containing a repeat unit with |FRAME: D-Glucose|, |FRAME: L-fucoses|, |FRAME: D-Galactose|, and |FRAME: GLUCURONATE| sugars that are nonstoichiometrically decorated with O-acetyl and pyruvate side chains |CITS: [4902806 ][4941627]|. The sugars need to be activated in the form of nucleotide sugars (|FRAME: CPD-12575|, |FRAME: CPD-13118|, |FRAME: CPD-14553| and |FRAME: UDP-GLUCURONATE|, respectively) prior to their assembly |CITS: [8759852] [8763957]|. The |FRAME: CPD0-1099| polysaccharide repeat is assembled on the membrane lipid |FRAME: CPD-9650| by a series of glycosyl transferases on the cytoplasmic face of the inner membrane, after which the single repeat is flipped to the periplasmic side and polymerized by the Wzy-dependent pathway (reviewed in |CITS: [12045108]| and |CITS: [16756484]|). Subsequently, the polymer is believed to be cleaved from the |FRAME: CPD-9650| anchor, transported across the periplasm, and excreted into the extracellular space, although this process is not well understood. |FRAME: CPD0-1099 "Colanic acid"| biosynthesis has been linked to a cluster of 19 genes, which were named wca |CITS:[8759852][8763957]|. This gene cluster is tightly regulated by a complex signal transduction cascade governed by the rcs (regulator of capsule synthesis) phosphorelay system |CITS: [3888955][16153174]|.

from BIOCYC source record: META_COLANSYN-PWY
Type: pathway
Taxonomic scope
conserved biosystem

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