Display Settings:


Send to:

Choose Destination

thiamin diphosphate biosynthesis II (Bacillus)

General Background : THIAMINE "Thiamin", also known as vitamin B1, is known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the anti-beriberi factor found in rice bran. Beriberi, a neurological disease, was particularly prevalent in Asia, where the refining of rice resulted in the removal of the thiamin-containing husk . The anti-beriberi substance was crystallized from rice polishings by Jansen and Donath in 1926 . The structure and synthesis of thiamin were reported by Williams . The compound was named thiamine when it was believed to be an amine. When it became clear that it is not an amine, the 'e' was dropped, and the name was changed to thiamin . Thiamin biosynthesis in bacteria is composed of the separate formation of the pyrimidine and thiazole moieties, which are subsequently coupled to form : THIAMINE-P (see : PWY-6893). About This Pathway This pathway describes the last part of the thiamin biosynthesis pathway - the coupling of the two moieties of thiamin, forming : THIAMINE-P, and its phosphorylation to the biologically active form, : THIAMINE-PYROPHOSPHATE. Although it is not absolutely clear at this time, it is possible that the key enzyme of the pathway, : BSU38290-MONOMER, acts in vivo on different substrates in different organisms. This pathway describes the process as documented in : TAX-1423.

from BIOCYC source record: BSUB_PWY-6893
Type: pathway
Taxonomic scope
organism-specific biosystem
Bacillus subtilis

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center