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Links from BioSystems

Items: 10

1.

RNA transport

RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
2.

Leukocyte transendothelial migration

Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
3.

T cell receptor signaling pathway

Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
4.

TGF-beta signaling pathway

The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
5.

Wnt signaling pathway

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways:...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
6.

Apoptosis

Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
7.

p53 signaling pathway

p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
8.

Cell cycle

Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
9.

MAPK signaling pathway

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
10.

Antigen processing and presentation

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus

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