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Links from BioSystems

Items: 1 to 20 of 85

1.

Bmal1:Clock,Npas2 activates circadian gene expression

Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
2.

BMAL1:CLOCK,NPAS2 activates circadian gene expression

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
3.

Circadian Clock

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
4.

Circadian Clock

At the center of the mouse circadian clock is a negative transcription/translation-based feedback loop: The Bmal1:Clock/Npas2 (Arntl:Clock/Npas2) heterodimer transactivates Cryptochrome (Cry) and Period (Per) genes; the Cry and Per proteins then inhibit transactivation by Bmal1:Clock/Npas2....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
5.

RORA activates gene expression

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
6.

Rora activates gene expression

Rora binds ROR elements (ROREs) in DNA and recruits the coactivators Ppargc1a (Pgc-1alpha) and p300 (Ep300, a histone acetylase) to activate transcription.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
7.

PPARA activates gene expression

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
8.

Circadian rhythm

Circadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of cell-autonomous transcription-translation feedback loops that drive rhythmic, 24-hour...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
9.

Mus musculus biological processes

Certain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian clock, Meiotic recombination, Meiotic synapsis, Signaling by leptin, Transcriptional...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
10.

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
11.

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
12.

Transcriptional activation of mitochondrial biogenesis

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
13.

Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes

The differentiation of mouse NIH3T3-L1 pre-adipocytes into adipocytes is the standard model system for adipogenesis.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
14.

Nr1d1 (Rev-erba) represses gene expression

Nr1d1 (Rev-erba) is a nuclear receptor that binds heme and acts, as far as known, exclusively as a repressor of transcription. Repression is achieved by the recruitment of corepressors by the Nr1d1:heme complex

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
15.

Mitochondrial biogenesis

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
16.

NR1D1 (REV-ERBA) represses gene expression

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
17.

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
18.

TRAF3-dependent IRF activation pathway

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
19.

Nuclear Receptor transcription pathway

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
20.

Transcriptional regulation of white adipocyte differentiation

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus

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