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Links from BioSystems

Items: 1 to 20 of 457

1.

EGFR tyrosine kinase inhibitor resistance

EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which activate down- stream pathways, are associated with cancers, especially lung cancer....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
2.

Glioma

Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), mixtures of various glial cells...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
3.

ErbB signaling pathway

The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
4.

Melanoma

Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
5.

Prostate cancer

Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
6.

Non-small cell lung cancer

Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
7.

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
8.

Negative regulation of the PI3K/AKT network

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
9.

Role of LAT2/NTAL/LAB on calcium mobilization

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
10.

Central carbon metabolism in cancer

Malignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. He...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
11.

Ras signaling pathway

The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
12.

PI3K/AKT activation

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
13.

PIP3 activates AKT signaling

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
14.

GAB1 signalosome

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
15.

Endocrine resistance

Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SERMs, e.g. tamoxifen), estrogen synthesis inhibitors (e.g. aromatase inhibitors (AIs)...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
16.

HIF-1 signaling pathway

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit. Under normoxia, HIF-1 alpha undergoes hydroxylation...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
17.

Endometrial cancer

Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
18.

Renal cell carcinoma

Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
19.

Choline metabolism in cancer

Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS and PI3K-AKT pathways, and transcription factors associated with oncogenesis such...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
20.

Acute myeloid leukemia

Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus

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